Incidence of hypercoagulability and thromboembolism in dogs with surgically treated primary hepatocellular and adrenal neoplasia
The goal of this study is to characterize the hemostatic abnormalities in dogs with primary hepatocellular or primary adrenal cancer undergoing surgical removal and to determine when their hypercoagulability (increased tendency for blood to clot) resolves post-operatively. Additionally, we aim to determine the incidence of thromboembolism (blood clots) in hypercoagulable patients diagnosed with primary hepatocellular or primary adrenal cancer following tumor removal.
What qualifies my pet for enrollment?
Eligible patients (any breed of dog) must meet all the following criteria:
- Dogs greater than 5kg in weight
- Dogs with primary hepatic or adrenal cancer
- Dogs must be free of endocrine disease, active hemoabdomen (blood in the abdomen), hepatic failure, renal disease (azotemia), anemia, and thrombocytopenia.
- Dogs not currently on anti-coagulant therapy
What does enrolling my pet in this clinical trial involve?
All patients enrolled in the study will undergo sedation for computed tomography (CT) examination of the chest prior to surgery. All patients will undergo surgical removal of the primary tumor. Blood collection will be performed prior to surgery, and at the 2, 3, and 4-week rechecks following surgery. An abdominal and thoracic CT scan, performed under sedation, will be done prior to (if clinically recommended) or at the 2-week recheck.
What are the potential benefits to my pet for participating in this clinical trial?
All patients enrolled in this study will receive current standard of care treatment. The findings of this study have the potential to inform knowledge and practice of surgeons.
Client compensation
The clinical trial will cover the cost of your dog's pre-operative chest and post-operative abdominal and chest computed tomography (CT) scan. Additionally, the study will cover the cost of each recheck examination fee and the cost of performing blood work (TEG, PCV/TS, platelet count and fibrinogen) pre and post-operatively.
Routine blood work (PT, PTT, CBC, chemistry panel, blood type prior to surgery) will not be covered by the study. The study does not cover the cost of your dog's pre-operative work up (primary tumor biopsy/FNA, pre-operative abdominal CT, thoracic radiographs, etc.), primary tumor removal, hospitalization, post-operative care, or additional oncologic care (radiation therapy or chemotherapy). Costs associated with adverse events (including but not limited to hematoma and incisional complications) are not covered by the study.
PRE-SCREENING QUESTIONAIRRE
If you believe your pet may be eligible to enter this study, please fill out a pre-screening questionnaire.